|Year : 2021 | Volume
| Issue : 2 | Page : 142-144
Severe hypercalcemia mimicking as ST-segment elevation myocardial infarction
KL Pradeep Yadav, Prakash Tendulkar, Ravi Kant
Department of Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
|Date of Submission||16-May-2021|
|Date of Decision||18-May-2021|
|Date of Acceptance||04-Jul-2021|
|Date of Web Publication||25-Aug-2021|
Dr. Ravi Kant
Department of Medicine, Division of Diabetes and Metabolism, All India Institute of Medical Sciences Rishikesh - 249 203, Uttarakhand
Source of Support: None, Conflict of Interest: None
The identification of ST-segment elevation on the electrocardiogram is an integral part of decision-making in patients who present with suspected ischemia. Unfortunately, ST-segment elevation is nonspecific and may be caused by noncardiac causes such as electrolyte abnormalities. We present a case of a 52-year-old male who presented with ST-segment elevation secondary to hypercalcemia in a patient with hypertension with osteoporotic vertebral collapse.
Keywords: Hypercalcemia, osteoporosis, ST-segment elevation myocardial infarction
|How to cite this article:|
Pradeep Yadav K L, Tendulkar P, Kant R. Severe hypercalcemia mimicking as ST-segment elevation myocardial infarction. Heart India 2021;9:142-4
| Introduction|| |
In cases of suspicion of myocardial ischemia, identification of ST-segment elevation is critical as emergent angiography is indicated for patients with ST-segment elevation myocardial infarction (STEMI). The finding of ST-segment elevation is nonspecific, and approximately 80% of patients who present with chest pain and ST-segment elevation are found to have a coronary lesion with thrombolysis in myocardial infarction Grade Flow of 0–1 at angiography., In addition, approximately 3% of patients with suspected STEMI are found to have angiographically normal coronary arteries. Electrolyte abnormalities including hyperkalemia,, and hypercalcemia may present with ST-segment elevation and a pseudo-infarction pattern on the electrocardiogram (ECG). In patients presenting with suspected STEMI, the decision to proceed with invasive angiography must often be made before laboratory results are available. In patients at risk for electrolyte abnormalities, clinicians must be aware of the common ECG changes associated with electrolyte abnormalities to avoid unnecessary procedural risks in a potentially unstable patient. The following reviews a patient with osteoporotic vertebral body collapse with hypertension (HTN) who presented with severe hypercalcemia and ST-segment elevation.
| Case Report|| |
A 52-year-old male was brought to the emergency department with complaints of generalized malaise, loss of appetite, vomiting, and altered behavior for almost a week's duration; it was associated with low-grade fever for 3 days and nonspecific chest pain. The patient was on injection teriparatide (20 mcg) OD for the past 2 months for osteoporosis and he was on regular antihypertensive medication. There was no history of headache, neck stiffness, and diabetes in the past. His examination revealed altered sensorium in the form of drowsiness and inability to follow verbal commands. His blood pressure (BP) was 180/90 mmHg with the unremarkable systemic examination.
- 2D ECHO: Concentric Left ventricular hypertrophy (LVH) with normal Left ventricular (LV) function
- Ultrasonography abdomen: Well-defined lesion in segment seven of the liver (? old abscess)
- Contrast-enhanced computed tomography thorax/abdomen: Benign lesions in the liver.
The patient was having severe hypercalcemia (calcium >14 mg/dl) [Table 1], he was started on isotonic saline at a rate of 200–300 ml/h with strict monitoring on fluid intake and output. Injection teriparatide was stopped and injection zoledronate (4 mg) was given. His antihypertensive medications were continued with strict BP charting. The patient symptomatically improved with correction of serum calcium in form of improvement in sensorium, resolution of ST elevation in 12 lead ECG [Figure 1] and [Figure 2].
|Figure 1: Standard 12 lead electrocardiogram suggestive of normal sinus rhythm and normal axis with ST elevation in lead V1, V2, and V3 with T wave inversion in lead V4, V5, V6, and reciprocal T wave inversion in lead I and aVL|
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|Figure 2: Standard 12 lead electrocardiogram s/o resolution of ST elevation in lead V1, V2, V3 after correction of hypercalcemia|
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| Discussion|| |
This patient presented with hypercalcemia and pseudo-infarction pattern on the ECG and appropriate treatment for hypercalcemia was initiated once laboratory results were obtained, The most commonly recognized manifestations of hypercalcemia on the ECG are shortening of QT interval with upsloping of the T wave On the ECG, the lower limits for the duration of QTc is not well-defined, but it is reasonable to consider a normal QTc interval as between 360 ms and 450 ms in males and 370 ms to 470 ms in females, interestingly, when this patient's serum calcium was 16.5 mg/dl the QTc was actually normal (370 ms) and ECG obtained after correcting hypercalcemia also shows normal QTc (376 ms), this case emphasizes that all ST-segment elevations are not due to myocardial infarction there are other causes which can lead to ST elevation like hypercalcemia.
| Conclusion|| |
ST-segment elevation is a known consequence of severe hypercalcemia and clinicians should be aware that high calcium levels may be associated with a pseudo-infarct pattern on the ECG. The possibility of electrolyte-induced ECG changes should be considered when evaluating the ECG for signs of ischemia.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient (s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initial s will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Dr Pradeep Yadav K L- manuscript writing -Dr Prakash Tendulkar- manuscript writing -Dr Ravi Kant- Supervision and editing.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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[Figure 1], [Figure 2]