Year : 2014 | Volume
: 2 | Issue : 2 | Page : 37--38
Preface to Second Issue of Heart India 2014
Alok Kumar Singh
Department of Cardiology, Heritage Hospital, Varanasi, Uttar Pradesh, India
Alok Kumar Singh
Department of Cardiology, Heritage Hospital, Varanasi - 221 005, Uttar Pradesh
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Singh AK. Preface to Second Issue of Heart India 2014.Heart India 2014;2:37-38
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Singh AK. Preface to Second Issue of Heart India 2014. Heart India [serial online] 2014 [cited 2020 Aug 7 ];2:37-38
Available from: http://www.heartindia.net/text.asp?2014/2/2/37/134576
I am delighted to present a second issue of Heart India to our esteemed readers and cardiologist of this continent with original contribution by our learned authors. Atenolol is a widely used antihypertensive drug worldwide. Despite well-studied from other population, there is paucity of data from Indian subcontinent. In this issue, Mukaddam et al. is reporting the result of hypertension on target with TENORMIN study-evaluation of the effectiveness and safety of atenolol in Indian population. This study is a simple data collection from physician office being treated for hypertension on atenolol. Statistically significant reductions (P < 0.05) were noted in both the blood pressures and heart rate at all the follow-up visits in comparison to baseline. Of the total 632 patients with Stage I hypertension, 153 (24.21%) achieved a reduction in blood pressure <120/80 mmHg, whereas 245 (38.77%) had their blood pressure between 121 and 140 mmHg systolic and/or 81-90 mmHg diastolic at 12 weeks of therapy. Global assessment of the efficacy and tolerability were found to be at least satisfactory in the majority of the study participants. Authors have concluded that, atenolol as an antihypertensive agent seems to be promising both in terms of effectiveness and safety profile in the Indian population. This is important to note this study was sponsored by Abott pharmaceuticals. In second original article by Ruiker et al. have reported corrected QT interval (QTc) among pregnant women during different gestational periods. This study was cross-sectional study, 202 pregnant individuals were selected from the antenatal clinic with different phases of pregnancy. All were subjected for electrocardiogram (ECG). QTc was calculated using Bazett's formula and QT intervals were correlated with duration of pregnancy. There was significant gradual increase in QTc with duration of pregnancy. There was significant positive correlation between duration of gestation and QTc (r = 0.277) (P < 0.001). Authors have concluded that QTc prolongation occurs as pregnancy proceeds.
Use of tobacco in cigarettes leads to an oxidant antioxidant imbalance. Long-term harmful effects of nicotine on various body parameters, including oxidative injury and a lack of antioxidants in the body are well-established. Fruits are known to be a rich source of natural antioxidants. Pakkala et al. have conducted to know the effect of consumption of fruits in a group of short term smokers on cardiopulmonary efficiency parameters. In this study, it appears that cigarette smokers are physically fit like controls, but after immediate smoking a lesser δHR suggests a higher risk for cardiovascular mortality. There seems to be no effect of including fruits in the diet of smokers.
Dilated cardiomyopathy (DCM) is mostly an idiopathic disease with a progressive and irreversible course. Rarely, a reversible metabolic etiology that is amenable to specific therapy is identified. Alteration in thyroid status can lead to changes in systolic and diastolic function of left ventricle. Heart is sensitive to thyroid hormone changes, and cardiac disorders are commonly associated with both hyper and hypothyroidism. Diastolic dysfunction is the most common abnormality reported in hypothyroidism. In systolic function, prolonged systolic time interval or normal cardiac function has been reported by most workers. DCM is a rare presentation of hypothyroidism. Here, Singhai report a case of 40-year-old female diagnosed with reversible DCM due to hypothyroidism.
Chest X-ray is a valuable modality that can point to the diagnosis in the appropriate clinical scenario. Abdulhalim J. Kinsara in second case report are presenting a chest X-ray of a rare disease that can be spotted if the X-ray was critically analyzed. In this case report, authors have highlighted how the right clinical approach can fasten the clinical diagnosis of relatively rare disorder such as multiple myeloma.
The extra-articular manifestations of rheumatoid arthritis (RA) have drawn as much interest as the disease itself and thus leading to it being labeled as a chronic inflammatory joint disease with a multisystem involvement. Of the various known extra-articular manifestations, one of the rare complications is the conduction abnormalities of the heart that is seen in the active disease. Here, Desai et al. in third case report, reporting a case of a female patient with RA, who to begin with had conduction defects secondary to RA, which later progressed to a complete heart block, as its sequelae. Hyperkalemia is a life-threatening metabolic condition that can induce deadly cardiac arrhythmias. Here, Dwivedi et al. in last case, reporting a case of severe life-threatening hyperkalemia in a 35-year-old man with preexisting renal impairment who was managed only medically with close ECG and vital monitoring. This case really gives very clear insight to those practionars, who are practicing in remote area where, there is no facility for temporary pacemaker implantation.