|Year : 2018 | Volume
| Issue : 3 | Page : 73-74
Preface to the third issue of Heart India 2018
Alok Kumar Singh
Department of Cardiology, Heritage Hospital, Varanasi, Uttar Pradesh, India
|Date of Web Publication||12-Sep-2018|
Dr. Alok Kumar Singh
Department of Cardiology, Heritage Hospital, Varanasi - 221 005, Uttar Pradesh
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Singh AK. Preface to the third issue of Heart India 2018. Heart India 2018;6:73-4
In this issue of “Heart India,” we are publishing one review article, four original research articles, and one case report. Several studies have shown an association between previous infections with chlamydia pneumonia, herpes simplex virus, cytomegalovirus, Helicobacter pylori, and hepatitis virus or respiratory tract infection and the presence of CAD, whereas other studies have not shown such an association. In the first review article, Agam et al. have discussed the role of herpes virus in coronary artery disease (CAD).
Strain and strain rate imaging (SRI) (deformation analysis) are more useful than wall motion analysis (velocity and displacement) for the detection of regional myocardial dysfunction. As the ventricle contracts, its muscle shortens in the longitudinal and circumferential dimensions (a negative strain) and thickens in the radial direction (a positive strain). Strain rate measures the time course of deformation and is the primary parameter of deformation derived from tissue Doppler. DSI is not affected by tethering or aliasing. SRI has been shown to quantify regional myocardial function in experimental studies with sonomicrometry, magnetic resonance imaging, and ultrasonography. It has also been established that DSI can be used to diagnose viability and some cardiomyopathies. In the first original research article, Sharma et al. have evaluated the usefulness of global and segmental peak systolic longitudinal strain (PSLS) and PSLS rate (PSLSR) measured by the Tissue Doppler Imaging (TDI) in identifying severe coronary artery disease (CAD). Authors of this study have concluded that PSLS and PSLSR were lower in patients having high-risk CAD that included left main and triple-vessel disease, even when resting wall motion and left ventricular ejection fraction were normal.
Left internal mammary artery (LIMA) is the most common arterial conduit used for patients undergoing coronary artery bypass grafting (CABG). Maintaining pleural integrity during harvesting has been documented to have better patient outcomes. In the second original research article, Kumar et al. have concluded that harvesting of LIMA for CABG extrapleurally has significant postoperative benefits and faster recovery compared to intrapleural approach.
Antithrombotic therapy in patients with non-ST elevation acute coronary syndrome (NSTE-ACS) includes dual antiplatelet therapy (DAPT) along with enoxaparin. However, resistance to the antiplatelet action of aspirin and clopidogrel is well known and is about 27% (0%–57%) and 30%, respectively. Hence, the use of glycoprotein IIb/IIIa inhibitor appears to be a reasonable option as they act on the final common pathway. In the third original research article, Bhandari et al. have concluded that tirofiban in addition to DAPT and enoxaparin reduces the risk of refractory ischemia, myocardial infarction, and death in patients with NSTE-ACS without any additional risk of major or minor bleeding.
In the fourth original research article, Nair et al. have studied the association of central aortic pressure to the severity of CAD. Authors of this study have concluded that central pulsatility was found to be most closely associated with the severity of CAD.
Moyamoya disease is a rare cerebrovascular problem often kept low in differential diagnoses of neurological ailments in accordance with occlusive involvement of the circle of Willis and its feeding arteries. Finally, Qadri et al. report a case of Moyamoya disease masquerading as recurrent headaches in a 4-year-old child.
| References|| |
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Yu XJ, Yang X, Feng L, Wang LL, Dong QJ. Association between Helicobacter pylori
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Vassalle C, Masini S, Bianchi F, Zucchelli GC. Evidence for association between hepatitis C virus seropositivity and coronary artery disease. Heart 2004;90:565-6.