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ORIGINAL ARTICLE
Year : 2014  |  Volume : 2  |  Issue : 4  |  Page : 93-98

The Effect of Gender on Heart Rate Variability and Uric Acid Levels among Subjects with Different Blood Pressure Profiles


Department of Physiology, M. S. Ramaiah Medical College, Bengaluru, Karnataka, India

Correspondence Address:
Dr. Kirthana U Kunikullaya
Department of Physiology, M S Ramaiah Medical College, Bengaluru - 560 054, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2321-449X.146606

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Context: Autonomic function is said to be different between males and females. Uric acid (UA) levels also vary with gender. We tried to explore if these differences exist among the subjects grouped based on their blood pressure (BP) profiles. Aims: The aim of this study was to compare the level of UA and autonomic function differences between males and females classified according to their BP levels. Settings and Design: This was a cross-sectional study conducted on 105 subjects classified into three groups according to Joint National Committee (JNC) VII criteria. Materials and Methods: Heart rate variability (HRV) was analyzed in Lead II electrocardiogram recording and UA levels were measured among 105 subjects after classifying them based on their BP levels according to JNC VII criteria. Statistical Analysis: Statistical analysis was performed using SPSS 18.0 version software. Chi-square test and Mann - Whitney U-test was used. Results: Males had significantly higher UA levels. The time domain parasympathetic parameters of HRV were higher among females on comparison with males indicating vagal withdrawal among males. The sympathetic parameters in the frequency domain were higher among males. This difference in HRV was observed among all BP profile groups. Conclusions: Males have a higher degree of vagal withdrawal and sympathetic activity as shown by HRV markers and UA levels. It is thus suggested that males could undertake more preventive measures and therapy at an earlier date than females. Further, treatment of male patients with hypertension should be much more vigorous than females.


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